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Intraduodenal activity of taste receptors reduces food intake. Taste receptors are expressed throughout the entire gastrointestinal tract. Currently, there are no data available on the effects of distal taste receptor activation. In a single-blind randomized crossover trial, fourteen participants were intubated with a naso-duodenal-ileal catheter and received four infusion regimens: duodenal placebo and ileal placebo DPIPduodenal tastants and ileal Polish massage Burnaby DTIPduodenal placebo and ileal tastants DPITduodenal tastants and ileal tastants DTIT. Fifteen minutes after cessation of infusion, subjects received an ad libitum meal to measure food intake.

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